Mount Sinai School of Medicine, USA: spinal tract diffusion MRI

Longitudinal multicenter cervical spinal tract diffusion MRI for progressive MS

Principal Investigator: Junqian Xu, Ph.D.
Institution: Mount Sinai School of Medicine
Country: USA
Amount Awarded: €74,841

Axons, also commonly known as nerve fibers, are the primary transmission lines of our nervous system. Destruction of axons during the course of MS has been found to be critically linked with long-term disability in people with progressive MS. Finding a way to accurately assess the stage and rate of axonal loss over time is key to developing new therapies that can protect or even regenerate axons to improve function. This team proposes to develop the infrastructure needed to facilitate clinical trials that track cervical spinal cord MRI measurements as a way of measuring the impact of potential therapies on MS damage and progression. The team proposes to use very high resolution cervical spinal cord MRI to study groups of people with progressive MS and controls without MS. This method will be used at two different sites and multiple times to ensure the quality of the findings.

What does this mean for people living with progressive MS?

Developing methods for tracking nervous system damage that occurs during MS progression is crucial for clinical trials that set out to determine the effectiveness of strategies at stopping or reversing this progression.


Project Update

Status: Extended to continue recruitment of trial participants


Principal Investigator: Junqian Xu

Junquian Xu

Junquian Xu

Junqian (Gordon) Xu, PhD, earned his BS from Peking University and his PhD in physical chemistry from Washington University in Saint Louis. He completed his National MS Society postdoctoral fellowship with a focus on spinal cord diffusion MRI at the John L. Trotter MS center, Washington University School of Medicine. He now conducts research in establishing highly reliable quantitative MRI biomarkers through an integrated technical development approach. His work in the field of in vivo diffusion MRI methods and applications has earned his recognition from Radiological Society of North America (RSNA) and International Society for Magnetic Resonance in Medicine (ISMRM).

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